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In addition, a systems approach is needed to provide a structural framework for national and local action. Eligible patients must have a diagnosis of metastatic cancer, have a baseline Brief Pain Inventory worst pain score of $3, be deemed by their physician to need initiation or up-titration of oxycodone-acetaminophen for pain control, and be able to read English. Results: Of 242 patients treated on study, 105 were randomized to continuous dosing, 101 to intermittent dosing, and 36 were not randomized due to disease progression at 8 weeks or other factors. The present manual sets out the prerequisites for the establishment of a nuclear medicine service. Antifogging agents in sticks and sprays are also available, but vary in their effectiveness. The bicarbonate must be in solution before the tricaine is added or an insoluble oil forms. This is the first time that a section primarily concerned with inequalities and cancer is being included in a World Cancer Report. Lymph node, dog: Neoplastic cells are small, with a moderate amount of cytoplasm and small round hyperchromatic nuclei. The water for making solutions should be double distilled or from a Milli-Q still (Millipore). Brain imaging was suggested for pts with suspected brain metastases, but was not mandated at screening or during treatment. Earlyphase transmission of Yersinia pestis by unblocked fleas as a mechanism explaining rapidly spreading plague epizootics. New-onset diabetes can be an early sign of pancreatic cancer, and it is being explored as a biomarker for early detection (as discussed below). The relevant epidemiological evidence is not sufficient, because bias, confounding, or chance cannot be excluded as contributing to the association that is evident, or because different studies provide conflicting results. Floor surfaces that cannot be completely decontaminated or where it is uncertain if further activity is present should be covered with a plastic sheet until the activity has decreased to a satisfactory level. All studies were read independently in triplicate for assessment of inter-observer agreement. For management, skin lightening agents +/emollients (36, 30%) or emollients alone (25, 21%) were highly recommended. Sterility testing of radiopharmaceuticals presents difficulties and it is often impracticable to apply tests described in pharmacopoeias; this is not only because of the radioactive nature of the material but also, as is the case with Tc radiopharmaceuticals, because the batch may consist of a single container. In the center large areas of amorphous acellular eosinophilic material is present (necrosis). Examples of such modulations are (i) gut microbial fermentation of dietary fibre into butyrate (and other short-chain fatty acids), which promotes epithelial health and prevents neoplastic transformation; (ii) gut microbial metabolism of primary bile acids into carcinogenic secondary bile acids; (iii) disruption of mucosal barriers by microbial mucus degradation and pro-inflammatory metabolites, which promotes cancer development; (iv) gut microbial drug metabolism and reversal of host detoxification processes; and (v) microbial immunostimulation. Mortality patterns in national populations: with special reference to recorded causes of death. In our ecological model, the rate of receipt of guideline concordant care declined by 0. The required level of protection can be achieved by viewing through lead glass screens or by using mirrors to view vials placed behind lead shields. Subjects with brain lesions must have received definitive treatment of the lesions. This helps clinicians to determine which patients to manage aggressively with invasive procedures and which ones to manage conservatively. Effective shortcourse treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis. The disorganized areas of bone are intermixed with "reactive" or reparative woven bone characterized by plump osteoblasts coalescing around, and oriented perpendicular to the longitudinal axis of woven bone trabeculae, thus demonstrating a structural uniformity distinguishable from neoplastic bone islands. Continuation of a software support contract is advisable as this will normally include any improvements, fixes of any bugs and new releases for a reasonable time. In negotiating purchases and contracts, attention should be paid to the service, warranty and supply of special consumable goods and spare parts, as well as special tools for quality control, service and installation. Lung, rabbit: Within areas of necrosis, numerous cells of various lineage contain eosinophilic intranuclear viral inclusions. Thus, immunostaining for these proteins is always used to distinguish between perineurial cell and Schwann cells.

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The particles are attracted or propelled by the alternatively charged D electrodes to gain higher energy and circle in the middle of the tank under the control of the magnets. Prevention of occupational cancer can be achieved through the use of lesshazardous materials, engineering controls, optimal procedures and training, and the use of personal protective equipment, together with the monitoring of exposure levels. Data from these questions, live poll responses, and learnersubmitted questions pre-event and during live Q&A were analyzed to determine engagement, lessons learned and continuing patient needs. Diagnosis is made by identification of the species-specific characteristic ova in feces, urine, or tissues (usually rectal and liver biopsy specimens). African American men with lowgrade prostate cancer have increased disease recurrence after prostatectomy compared with Caucasian men. Malignant cells of neuroendocrine origin express a high number of receptors for various hormones and peptides. In some cases, notably with radiopharmaceuticals that target normal bone, it may be necessary to define more compartments. Thus, we performed a prospective cohort study with historical comparison for four years. Results: Cumulative incidence of neuromuscular dysfunction was elevated at 20 years from diagnosis in survivors (24. Although douncing works (see Note 20), we get a greater yield of Wee1 and Wee2 protein by using a sonicator to disrupt the cells. Identification of a novel herpesvirus in captive Eastern box turtles (Terrapene carolina carolina). As there is a higher incidence of infections in the elderly population in general, caution should be used when treating the elderly. Further, it yields information on the presence, relative size and shape, and preliminary identification of microorganisms. Areas where unsealed radionuclides are used are classified as low, medium or high hazard, the hazard level determining design requirements. Molecular footprints of muscle-invasive bladder cancer in smoking and nonsmoking patients. These studies have provided some insights for planning future prospective prevention trials. These results support the patientcentered benefits of weight loss in this population. Restrictions on advertising and marketing Many countries have long restricted advertising of unhealthy foods directed at children. Subjects who regularly use aspirin (defined as $ 5 days per week) need to stop 30 days prior to enrollment. Results: We identified 14 studies, 10 in ovarian, 3 in breast, and 1 in pancreatic cancer patients. We will present a comprehensive case report of a patient with dramatic and durable response. Their main use is to aid a decision on splenectomy in patients with idiopathic thrombocytopenic purpura. Heart, alpaca: There are widely scattered areas of myocardial degeneration and necrosis. The simplest compartmental model is the exponential clearance model, which assumes that the radiopharmaceutical leaves the compartment at a constant exponential rate, which is then used to fit the data to an exponential curve. Prepare a replication start mixture containing for each replication assay (see Note 10): 0. Red meat and processed meat also contain salt; high dietary salt intake, low intake of fresh fruits and vegetables, and tobacco smoking are behavioural factors that increase the risk of gastric cancer [2]. You should also change the pipette tip every time antigen is taken out of the bottle. No increase in serious adverse events was noted although endocrine therapy related toxicities were not specifically collected.

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Many of these genes are now tested in clinical settings, but the number of variants identified has exceeded the threshold for adequate interpretation [10]. Mean vaccination costs per dose were summarized by vaccine brand and health plan type. It must include improvement of data related to Indigenous peoples, including Indigenous identifiers, which will enable Indigenous peoples to identify and prioritize their health needs [7,42]. The 5-year relative survival is more than 80% for chronic lymphocytic leukaemia and chronic myeloid leukaemia but less than 20% for other subtypes, such as acute myeloid leukaemia. Processed meat is defined as meat that has been transformed through salting, smoking, curing, and/or fermentation to enhance flavour or for preservation (examples are frankfurters, bacon, salami, deli meats, and similar products), whereas red meat refers to unprocessed mammalian muscle meat. Gross Pathology: At necropsy, the dog had a poor condition score with pale and subicteric mucous membranes. For example, a Coulter counter can be used to measure cellular proliferation in infected compared with noninfected cells (10) and the cell cycle profiles of infected cells compared with noninfected using flow cytometry. Interpretation Normally the kidney contours are smooth and rounded with a contrast between the outer cortical part and the less active medial portion of the kidneys. Analysis of the calculus showed that it was composed of 100% calcium oxlate dihydrate. Patients who initiated treatment at outside institutions were included if they were prescribed treatment at appropriate doses and if complete records were available. Ongoing work will directly evaluate the bone marrow dosimetry of various treatment approaches using phantom-based modeling. Fluorescence microscopy also has been used to enhance accurate sediment evaluation. Identification of ten variants associated with risk of estrogen-receptornegative breast cancer. Thermal injury may impair the barrier function of the oesophageal mucosa, thereby increasing exposure to intraluminal carcinogens such as N-nitroso compounds and polycyclic aromatic hydrocarbons. Data in premenopausal women have been sparse, largely because of complexities in measuring estrogen levels during the menstrual cycle. Polyuria and polydispsia resolved within 4 days and the dog appeared to be normal 2 years later. As discussed by the contributor, the observation of viral protein inclusions and brown pigment within the tubular epithelium was f u r the r complicated by the prominent acidophilic granules common 3-7. Long-term use of about 10 years was estimated to reduce overall cancer incidence by about 9% in men and 7% in women, and overall cancer mortality by 13% in men and 9% in women (Table 6. This implies that prevention of obesity is a priority for the prevention of cancer, as well as cardiovascular diseases and diabetes. Gastroenteritis Adenovirus Standard n/a Use Contact Precautions for diapered or incontinent persons for the duration of illness or to control institutional outbreaks. Normal non-dysplastic cervical squamous epithelium is present at the periphery (top right and top left). Particular micronutrients and supplements for cancer prevention have been subject to large clinical trials, but few, if any, benefits have emerged, and evidence of increased risk has accrued. A large body of animal investigations and a more limited number of clinical studies have established the ability of ionizing radiation to reduce significantly neointimal proliferation and the restenosis rate. Multivariate analysis controlling the effect of different clinical variables is shown in the attached table. Two grade 2+ toxicities were observed, both in surgical patients: deep venous thrombosis and ureteric injury requiring stent placement. A thick pale eosinophilic to pale blue capsule surrounds the bradyzoites contained within a parasitophorus vacuole. Characterization of vascular lesions in pigs affected by porcine Circovirus type 2-systemic disease. The presently examined pig was one of two in the breeding unit submitted for necropsy. Hazmat suits (hazardous materials suits) are an example of personal protective equipment, an option to be used to control workplace exposures to occupational carcinogens. Subsequent anticancer therapies included docetaxel (95%), enzalutamide (25%), cabazitaxel (24%), abiraterone (12%), lutetium-177-prostatespecific membrane antigen (4%), and sipuleucel-T (1%).

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Research Sponsor: Our Clubhouse is a community-based non-profit organization funded primarily by individual contributions and partnerships with regional healthcare systems, specifically University of Pittsburgh Medical Center, Allegheny Health Network, and Excela Health. A 24 hour image will show fading in a rheumatoid joint or other active inflammatory arthropathy but there will be persistence of uptake in septic arthritis, since binding to the dividing bacteria persists. Given that some groups are more likely than others to have co-existent chronic conditions, comorbid conditions may play a role in prostate cancer disparities in treatment and outcomes. There was one grade 3 immune-related adverse event (colitis) requiring study discontinuation. These inequalities emphasize the continued need to strengthen the infrastructure for immunization systems, especially in low-income countries. A Global Burden of Disease analysis published in 2014 concluded that despite a decline in smoking prevalence from 1980 to 2012, the number of daily smokers increased from 721 million to 967 million [36]. Our approach is time-efficient, reproducible, and requires minimal resource allocation, thus overcoming multiple common barriers to generalizability for contemporary biomarkers. Comparisons were made between patients regarding surgical parameters and oncologic outcome and multivariate models were used to identify factors independently associated with disease recurrence. The test tube should be centrifuged at 1000 to 1500 revolutions per minute (rpm) for 3 to 5 minutes. The availability of specific features, software or accessories that meet the defined function is likely to be one of the main deciding factors in selecting a suitable system. Cdks have also been found to be deregulated in some tumors; for example, Cdk4 is mutated in melanoma (39,40), and Cdk2 expression is increased in some breast cancer cells (41). Geographic disparity of outcome in patients with cancer over decades: the surveillance, epidemiology, and end results. Epigenetic modulators, modifiers and mediators in cancer aetiology and progression. Urothelial carcinoma in situ is characterized by flat, disordered proliferation of urothelial cells with marked cytological abnormalities. Also, these estimates do not account for errors in measuring diet or the potential effect of diet during childhood or early adult life. Hemothorax = blood in pleural space (ruptured Aorta, Penetrating trauma) without inflammatory cells. In those populations, melanomas are the most common cancer type in people younger than 40 years, and are among the most common cancer type overall. Incidence rates of prostate cancer are highest in North America, Europe, Australia, and New Zealand. Among the 387 patients without a prior breast cancer history, 21 patients developed a subsequent cancer; 10 in the surgical group and 11 in the observed group (7. All patients should be scheduled for follow up with their primary care provider within several days following an episode of severe asymptomatic hypertension. Genotype and phenotype correlation of common cancer predisposition syndromes in sarcoma cases. The patients may have had a very large spleen (often combined with an enlarged liver) for years. However, breathing rates during activities requiring heavy exertion may produce peak inhalation air flows exceeding 115 L/min. Methods: Pelareorep (P), Carfilzomib (K), and dexamethasone (d) were all infused on days 1, 2, 8, 9, 15 and 16 of a 28-day cycle. Absolute treatment effect of S-1 was estimated in each risk group defined by the composite risk score. Grade 3) were neutropenia 50%, fatigue 8%, peripheral sensory neuropathy 8%, appetite loss 4%, diarrhea 4%, febrile neutropenia 2% and allergic reaction 2%. Molecular epidemiology of Helicobacter pylori infection in a minor ethnic group of Vietnam: a multiethnic, population-based study. Thymidine (Sigma-Aldrich): prepare a 100X stock of thymidine (250 mM) by dissolving 0. There have been various attempts to reduce the number of biopsies for benign lesions in order to save costs and to avoid the psychological impact on those patients who are left with a scar following lumpectomy. Morphologic characterization of alveolar macrophages from subjects with occupational exposure to inorganic particles. Proposals for non-commercial reproductions and translations are welcomed and will be considered on a case by case basis.

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The cancer burden due to alcohol is preventable the current burden of cancers caused by alcohol consumption is large, and this burden is expected to increase in the future. When spore-con taminated material is likely to fall from overhead, workers should wear disposable protective clothing with hoods. Therefore, data on these characteristics can provide independent evidence of carcinogenicity when data from studies in humans are lacking. Levonorgestrel-releasing intrauterine system use is associated with a decreased risk of ovarian and endometrial cancer, without increased risk of breast cancer. Use of oral contraceptives is related to substantial reductions in the risk of endometrial cancer and ovarian cancer, and the reduction in risk persists for extended durations after discontinuation of use. This study was approved by the ethical committee of Sun Yat-Sen University Cancer Center. In this context, dysplasia is the ideal surrogate marker for cancer, and its detection in asymptomatic individuals is seen as the best way Chapter 6. Results: Among 379 enrolled pts, 213 pts received esophagectomy and the remaining received chemoradiotherapy. Orthostatic hypotension and tachycardia occur more acutely but are insensitive and nonspecific signs. Even at age 50 years, quitting results in an average of 6 years of life expectancy gained [11]. The use of denosumab for surgical downstaging and reduction of recurrence is being studied, but the standard of treatment is still surgical. Koningic acid was identified as a highly specific inhibitor of glyceraldehyde 3-phosphate dehydrogenase, a rate-controlling enzyme in the glycolytic pathway, with limited perturbations of other metabolic pathways [8]. In this clinical into the bladder lumen setting, puncture of at an oblique angle to the cranial pole of the reduce the possibility bladder should be of urine leakage after avoided because the the needle is withbladder will be drawn drawn. Benefits of an early mobility program for hospitalized cancer patients: A pilot study. We report our institutional experience on the rate and etiology of readmissions after initial discharge. In women, the five major cancer types accounted for more than 50% of the burden in each of these three indicators. Left ventricular enddiastolic volume may be measured using the geometric or count proportional method. Also, for asymptomatic, exposed infants delivered vaginally or by C-section and if mother has active infection and membranes have been ruptured for more than 4 to 6 hrs until infant surface cultures obtained at 24-36 hrs. About 14 days later the keepers suggested that the animal was not pregnant, but an abdominal swelling was reported. These sessions covered the key areas identified by the Systemic Therapy Day and Acute Oncology Units. Finally, it is noteworthy that immune checkpoint inhibitors have recently emerged as novel potential therapeutic options [29,30]. Occasionally, however, magnification is needed for accurate localization of the fracture, differential diagnosis between bruise and fracture, and detection of an occult fracture. Broader professional engagement with cancer control and a need for information by journalists, governments, and community-based cancer-oriented authorities and the teaching profession is also recognized. Methods: In this study we utilized Nanostring immune profiling technology along with multiple in vitro and in vivo assays were used to study the role of Kaiso in breast cancer immune escape. Options are available for cancer risk reduction in carriers, including lifestyle changes, enhanced surveillance, chemoprevention, and risk-reduction surgery. Some of these airways are close to the pleural surface and inflammation extends into and through the pleura, forming a nearly diffuse coagulum of fibrin, foamy macrophages, multinucleate giant cells and few lymphocytes and plasma cells on the pleural surface. In the all-exposure population, the elevations in lipid parameters remained consistent with what was seen in the 24 week, controlled clinical trials. Technetium-99m is eluted from the generator by drawing sterile saline through the column. We had previously created and tested educational videos about basic chemotherapy terminology for use in an underserved population at our inner-city hospital.

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Specific phylotypes in oral flora have been associated with risk of pancreatic cancer in a large prospective cohort study of the oral microbiome, suggesting that microbiome signatures also hold promise as biomarkers for early detection [29]. Histopathologic Description: Throughout grey and white matter as well as within meninges, there are multiple randomly distributed necrotic foci, composed of central debris, sometimes associated with bright eosinophilic material (Splendore Hoeppli phenomenon), and surrounded by numerous degenerate neutrophils and macrophages besides fewer lymphocytes and plasma cells. Trajectory clustering identified four distinct trajectories: Temporary Improver, Temporary Deteriorator, Improver, Inexorable Deteriorators. Hepatic Impairment No formal study of the effect of hepatic impairment on the pharmacokinetics of tocilizumab was conducted. Using a 4-point Likert scale, interest in hematology-oncology decreased overall from 3. However, in many of these same areas childhood mortality remains high, in part because of inadequate food availability and unmet nutrition needs of growing children. The finding of totally fixed defects with an otherwise normal cardiac global function also indicates a benign prognosis. Worldwide trends in gastric cancer mortality (1980-2011), with predictions to 2015, and incidence by subtype. There are several hypothesized biological mechanisms involved in the association between physical activity and cancer risk, including an effect on adiposity, endogenous sex and metabolic hormones, chronic inflammation, oxidative stress, and genomic instability [4]. In some cases, it is preferable to apply these labelled probes directly to cells and tissues to localize the source of the signal. At the end of the 10-min incubation, discard the used equilibration buffer I in its entirety by carefully decanting the liquid from the tray. Driving action to prevent cancer and other non-communicable diseases: a new policy framework for promoting healthy diets, physical activity, breastfeeding and reducing alcohol consumption. Although the samples measured in this procedure contain all the reaction components from the Cdc2 kinase assay (see Subheading 3. Smoking cessation remains the most widely established means of cancer prevention, and new insights are offered in this World Cancer Report. Post-randomization central testing of tumor tissue (collected prior to enrollment) will be carried out to identify predictive markers of sensitivity to treatment. Genetics, genomics, and cancer risk assessment: state of the art and future directions in the era of personalized medicine. Three phase scintigraphy is useful, revealing increased blood flow and blood pooling, which denotes hyperperfusion. Clinical breast examination: preliminary results from a cluster randomized controlled trial in India. In particular, the ability to easily add simple programs is important to permit flexibility in use. Surgical gamma probes the use of surgical probes for localization of activity which can be traced and surgically excised has been of interest since 1949. The convergence of biological mechanisms in ageing and neoplasia is explored by relating the effects of telomere dysfunction on cellular senescence and genomic instability. The median change in allele fraction at the first ontreatment blood draw was -90% (range: -100 to +65), -71% (range: -100 to +100) and +35% (range: +17 to +100) in pts with subsequent radiological response (N = 11), stable disease (N = 11) and progressive disease (N = 7), respectively (P, 0. Methods: We applied a highly-multiplex Proximity Extension Assay to simultaneously detect. Occasionally, a common genetic marker may point towards a less common variant with a stronger effect, known as a synthetic association [19]. Muchmore, "Immunoblot analysis of antibody responses to Sporothrix schenckii," Journal of Clinical Microbiology, vol. Conclusions: this is the first exploratory report of serum choline levels in pan-cancer pts receiving pembrolizumab. About 20 of these countries either already vaccinate boys in addition to girls or plan to do so. An exploratory endpoint was added to evaluate clinical effects (physical activity, treatment-related symptoms, and quality of life) using a smartphone app. This infusion is performed with a plastic sheet between the syringe and the patient so that any spills will not result in contamination of the patient. However, regenerative tubules with juvenile epithelial cells, interstitial fibrosis and mild to moderate mesangial proliferation suggest a differential diagnosis of tubular nephritis following renal injury, such as toxicosis or leptospire infection. We matched survivors by age and geographic region to females without a prior cancer diagnosis.

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Results: 506 women underwent surgery as follows: 216 unilateral lumpectomy (43%), 181 unilateral mastectomy (36%) and 109 bilateral mastectomy (22%). Methods: Adult breast cancer patients with metastases to bone, admitted from January 2012 to September 2015 were identified from the Nationwide Inpatient Sample database. To our surprise in E1 contained the three interacting proteins but not the bulk of Ndc80. However, incidence and mortality data remain extremely limited for several world regions, such as Africa. Overall, 24/368 pts (7%) died of acute treatment toxicity (pulmonary [bleomycin n=10, radiation n=1], infection n=10, cardiac n=3). Included trials were interventional (as opposed to observational), were closed between 2004 and 2019, enrolled ovarian cancer patients, had submitted results, and were open at one or more domestic sites. Reporting Details should be provided on the radiopharmaceutical used, the site of injection, waiting period, projections acquired and the intensity of uptake, as well as the confidence in the interpretation. Geographical patterns of colorectal cancer incidence and mortality are related to indexes of development. There were 29 pts of osteosarcoma, 9 pts of chondrosarcoma, 3pts of Ewing sarcoma and 1 pt of bone derived malignant fibrous histiocytoma. Cancer in Aboriginal and Torres Strait Islander peoples of Australia: an overview. This means actively identifying and addressing social, economic, and political structural barriers, which hinder the attainment of equitable health for Indigenous peoples. The environment needs to be protected from unintentional discharges of radioactive material from the radiopharmacy. This is monitored for contamination; if clear the drapes can be laundered, if not they should be stored until the activity is low enough for them to be cleaned. Methods: For the study breast cancer patients were recruited from San Cecilio University Hospital in Granada (Spain) who were treated with trastuzumab. These dramatic changes in living standards in Golestan are probably the main reasons for the sharp decrease in incidence rates of oesophageal squamous cell carcinoma [29]. In the brain and spinal cord, there was moderate purulent subdural exudate (meningoencephalitis). There were multifocal, round, tan, slightly raised nodules ranging from pinpoint to 4 mm diameter throughout all lung lobes, but affecting less than 1% of the pulmonary parenchyma. A pinhole collimator can be aligned to any desired angle, permitting all-angle imaging, a distinct technical advantage. The thyroid does not need to be blocked, but some thyroid uptake may be seen if there is a delayed injection. The onset and duration of these clinical signs was not reported and could not be obtained. The levels of each species can be determined by scanning the stationary phase with a suitable detector or cutting it into sections and placing each in a counter. The efficacy of the combination therapy is similar to that of the pentavalent antimonials monotherapy, with the advantage of a decreased toxicity, shorter treatment duration and cheaper cost. Glycogen is a crucial source of energy stored in myocytes and in variable amounts within hepatocytes. In Mexico, an excise tax of 1 peso per litre on sugar-sweetened beverages, which was successfully implemented on 1 January 2014, resulted in a 5. Circulating tumor cells in breast cancer patients treated by neoadjuvant chemotherapy: a meta-analysis. Listeria monocytogenes septicaemia in an inland bearded dragon (Pogona vitticeps). There were no major differences in acute toxicity: 68% of patients in Arm A experienced serious adverse events and 67% in Arm B.

References:

• https://thepafp.org/website/wp-content/uploads/2017/05/2014-JNC-8-Hypertension.pdf
• https://www.supremecourt.gov/opinions/10pdf/09-1233.pdf
• https://www.thelancet.com/pdfs/journals/lancet/PIIS0140-6736(95)92595-3.pdf