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We identified prospective key events using recent literature on ionizing radiation and carcinogenesis, focusing on review articles. Focal nodular hyperplasia, which has a characteristic gross appearance of a central stellate scar within the tumor, microscopically reveals hepatic nodules surrounded by fibrous bands having numerous proliferating bile ducts. The tumor does not connect to the overlying epithelium and is found only in the wall of the stomach. Stomach, pigtailed macaque: There is diffuse necrosis of the gastric mucosa, and necrosis mixed with hemorrhage and edema within the underlying mucosa. Applying such models, we have established that inhaled toxicants (nanotubes, ozone, diesel exhaust) drive systemic inflammatory signals carried by the circulation, and this outcome is consistent in humans and laboratory models. Rather elastic term conventionally restricted to immune and haemopoietic system; many made by T cells or macrophages. Introduction the basic reproduction (or reproductive) number (or ratio) is a fundamental concept in epidemiology. These cancers spread locally requiring the ability of tumor cells to colonize the peritoneal organs following escape from the bladder. Clinically the bullae are large, flaccid, and easily ruptured because of their thin roof. The Supervising Officer shall refer the matter immediately to the Senior Chief Executive, Ministry of Civil Service and Administrative Reforms, specifying the reasons why the officer cannot be released and stating the date on which the officer could, according to him, be granted such leave. I certify that to the best of my knowledge that the information given above is correct. Microscopy of the nodules revealed questionable remains of parasites, but the X-ray showed crescent- or horseshoe-shaped calcifications that were attributed to Armillifer (Mulder, 1989). Ancylostoma duodenale and Necator americanus are exclusively human parasites, although the former infects dogs and cats under experimental conditions (el-Naggar et al. Histologically the myocardial fibers exhibit disarray, caused by wide fibers with unusual orientation, and prominent hyperchromatic nuclei. Control: the application of pesticides (insecticides, development regulators, hormonal analogs, etc. Pulmonary adiaspiromycosis was observed in all wild wombats culled concurrently from this site. Overall, these results suggest that apoptotic cell death, as opposed to necrosis, is a more procoagulant form of hepatocyte cell death. Results show that triclosan did not induce changes in litter size or pup body weight. Four different aerosols were produced in a light stove: wood smoke (spruce), flow tube aged wood smoke (spruce), lignite smoke, or flow tube aged lignite smoke. After discovering this, the doctor swabbed me inside with antifungal and sewed me up with no implants. These are called "eclipsed" antigens, since these antigens by resembling those of the host are not recognized as foreign and therefore are hidden Parasitology 21 from the immune recognition. The lemur recovered from anesthesia but continued to have labored breathing and lethargy. For special damages in an amount to be proven at the time of trial; For exemplary and punitive damages in an amount to be proven at the time of trial, an 15 16 17 sufficient to punish defendants or to deter them and others from repeating the injurious conduct allege. Parasitology 83 General Life Cycle SporozoitesTrophozoitesSchizontesMerozoites GametocytesGametesZygoteOokinetOocyst (SporoblastsSporocysts). If your doctor told you that you had incurable cancer, you would want a second opinion. Leaf characteristics have proven particularly useful in differentiating two or more species that are nearly identical in other visible traits. Applications are numerous and silicones are found in industrial, pharmaceutical, medical device and personal care products. Protect Yourself When Testing Protect yourself against mold spores when you are testing various areas of your home by wearing: 1. In addition, rats are known to be carriers of diseases such as the bacterium Leptospira, which can result in Leptospirosis disease in humans.
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With the advent of agriculture, the dramatic rise in population and the settlement of people in close proximity to their waste led to increases in human disease; the domestication of animals led to livestock pathogens jumping species into people, where they became the probable cause of diseases such as diphtheria, influenza, measles and smallpox. The tissue removed from the nasal cavity and frontal sinus are found to be distorted in a histologically similar manner. While natural language processing-based information retrieval technologies are now widely used to increase the efficiency of the upstream literature screening and prioritization steps in systematic reviews, the use of information extraction algorithms in data extraction is still nascent, potentially owing to the lack of publicly available annotated datasets. Incentivize proven and under-used animal husbandry management, biosecurity and zoonotic disease control measures for industrial and disadvantaged smallholder farmers and herders. Selenium deficiency does not only occur in managed feed situations, but also in pasture-raised livestock. As nicctine drives smoking behavior (Picciotto and Kenny, 2013), we adjusted the concentration of the extracts so that the same amount of nicotine was consumed by our smoking/vaping apparatus per final volume of cell culture medium. Clinical signs are acute and include fever, ataxia, seizures, convulsions, opisthotonos, coma and death; mortality is high. There are multiple, coalescing foci of purulent material (abscesses) within the quadriceps and hamstring muscles. This indicates that functional, clinically-relevant measurements represent a more sensitive metric. However, it is extremely difficult to recreate the complex, stratified 3D architecture of the human retina featuring a large number of cell types within an OoC in its entirety. There was a good concordance between the models regarding the rate of metabolism and metabolites produced for 8 chemicals. For information on reducing sample size, refer to the Guidelines for Calculations and Sampling. Our results showed significant neurite regression in response to the drug thalidomide at high concentrations. Furthermore, it is not clear if these impairments are the cause or consequence of cytotoxicity. Jaundice secondary to extrahepatic obstruction is associated with normal hemoglobin levels, normal serum indirect bilirubin levels, and increased levels of direct bilirubin and alkaline phosphatase. We found that plating cells under controlled, constant temperature conditions did eliminate swings in well temperatures during cell plating and cell settling that were produced by plating cells in uncontrolled room air conditions. We hypothesized that carbon nanotubes promotes atherosclerosis due to enhancing inflammatory responses triggered by inflammasome activation. History: this rabbit was part of a study to determine the median lethal dose of aerosolized ricin. First it is necessary to determine whether the blasts have B cell or T cell markers. Session organizers believe that the learnings from the reported proof of concept read-across approaches will help to develop new mechanism-based chemical safety testing strategies. High throughput techniques make it feasible to measure and analyse thousands of different proteins, genes and metabolites in tiny samples of tissue or blood: in the medicine of the future, these technologies will be used increasingly for diagnosis, and the development of ever more individualized medical treatments. This phenomenon facilitated the breeding of modern sugarcane cultivars as the "officinarum" qualities recovered more quickly in the hybrids, thus requiring fewer rounds of backcrossing to produce high sucrose cultivars (Sreenivasan et al. Trim5 binds retroviruses and carries them to the proteasome, an intracellular organelle that destroys them. Where an officer wishes to retire under sub-paragraph (1) (d), he shall submit a request to his Responsible Officer stating the reasons therefor, and, at the same time, forward his birth certificate in original and other relevant documentary evidence. Disadvantages include inactivation by organic matter, and vapors may pose a hazard to respiratory organs. Marginal bone (the bone level just below the gum line) may not be visualized with high contrast, so lower contrast, which may be a bit less clear, is preferred in many instances. In intensive swine confinement operations, H2S is a hazard for both humans and swine. Multisystemic abscesses in African green monkeys (Chlorocebus aethiops) with invasive Klebsiella pneumoniae-identification of the hypermucoviscosity phenotype. Recent research has also discovered a whole range of molecules blocking viruses from becoming established in cells. Ticks of the genus Ixodes are parasites of birds as well as large and small mammals and are distributed worldwide. Spray a protective fungicidal coating on all remediated-surfaces prior to rebuilding and closing in the mold-remediated area.
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It is valuable tool to limit the number of analogue chemicals when performing read-across. Where feasible, preventing and mitigating their occurrence in humans requires their elimination in their animal reservoirs. A blue nevus is composed of highly dendritic melanocytes that penetrate more deeply into the dermis. Conference Comment: the contributor provides an excellent description of amyloidosis, and our comment will only elaborate on some other details of this important pathologic condition in animal species. The phagocytosed bacteria will be detected using confocal fluorescence microscopy. The main arteries have atheromas that are similar to systemic atherosclerosis, but are not as severe. Ruddock As oral delivery of therapeutic proteins is often viewed as attractive for supporting patient compliance, the principal drawback is that these macromolecules are too large to pass through the epithelial and endothelial barriers without an absorption-enhancer. Histologic changes include rounded, atrophic fibers; hypertrophied fibers; degenerative and regenerative changes in adjacent myocytes; and necrotic fibers invaded by histiocytes. Or they can react with target autoantigens in blood, forming large complexes (see Figs 20 and 36), which accumulate in skin, lung or kidneys causing inflammation and organ damage. The information in these guidelines is intended only as a 123 summary of basic procedures and is not intended, nor should it be used, as a detailed guide to mold remediation. Systemic mycobacterium avium infection in a dog diagnosed by polymerase chain reaction analysis of buffy coat. Laboratory examination reveals increased serum uric acid and cholesterol with decreased serum glucose levels. The skin in these patients is fragile and hyperextensible, while the joints are hypermobile. Conference participants discussed the following common clinical sequella to this neoplasm. Small intestine, sheep: There is marked crypt loss and remaining crypts are separated by large numbers of macrophages with abundant eosinophilic cytoplasm. The virus has a narrow tropism that is limited to the upper and lower respiratory epithelia as well as the conjunctival epithelium. Vitamin K is required for the posttranslational conversion of glutamyl residues in some proteins into -carboxylates. Shrubs that grow close to the foundation are trimmed so that there is 1 foot of air space around the house. Chickens usually have a chronic disease with pasteurellosis, with infection in the combs and wattles. Cd exposure increased the populations of apoptotic cells and sub-G1 hypodiploid cells. A third issue that requires resolution is the fact that the outcome of remediation experiments may vary depending on the scale of the experiment. Once ingested by the equine host, they continue to mature, and, in a rapid life cycle, new eggs may be passed onto the pasture in as few as 5-6 weeks. The purpose of this course, to be delivered by a mixed group of experts from government, academia, and industry, is to provide participants an overview of the currently prevailing dose-response modeling methodologies and tools with case studies and applications in chemical risk assessment. Zebrafish (Danio rerio) has been the promising model to identify toxicity mechanism using various molecular techniques. A subset of >1000 chemicals that had been evaluated in at least three independent rat oral acute toxicity studies were used to assess variability. Nicotine is the principal neuroactive chemical in tobacco and is central to the addictiveness of tobacco. Because of their dual blood supply, arterial occlusion of either the hepatic artery or the portal vein rarely results in liver infarcts. This question is addressed through four examples that illustrate the usefulness of the basic reproduction number in mathematical epidemiology. Low numbers multifocally contain karyorrhectic debris and of coccidial (1+) oocysts were seen on fecal degenerate neutrophils (crypt abscesses). Additionally, significant variability in the execution of the assay can be introduced by small changes in input material processing. Various structural similar phenolic compounds are liable for causing oxidative stress-mediated cytotoxicity.
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This treatment method provides a simple, effective way to improve air quality, especially because methane is now regarded as an undesirable atmospheric gas because of its contribution to the greenhouse effect and smog formation. This results from a block in the metabolism of the phenylalanine-tyrosine pathway, which is caused by a deficiency of homogentisic oxidase. Infants are normal at birth, but rising phenylalanine levels (hyperphenylalaninemia) result in irreversible brain damage. The third type of angina is unstable angina, which is characterized by increasing frequency of pain, increased duration of pain, or pain that is produced by less physical exertion. To characterize neurobehavioral requirements for microbial colonization, we isolated strains of Actinetobacter, Comamonas, and Comamonadaceae from 10 dpf colonized zebrafish. Despite over 40 years of research, there is still no 100% effective vaccine (but see below). Taken together, further fractionation of plant extract is warranted to explore hepatoprotective activity from a single active fraction. White spots or a cloudy film may develop on damp furniture that has not been submerged. Idiopathic thrombocytopenic purpura Thrombotic thrombocytopenic purpura Disseminated intravascular coagulopathy Submassive hepatic necrosis Waterhouse-Friderichsen syndrome 218 Pathology 204. S 1672 Diverse Methodological Approaches to Investigate the Endothelial Impacts of Toxicants and Systemic Inflammation S M. The aim of this study was to investigate the antibacterial activity and safety in vitro of the leaf extracts against eight Salmonella serovars. The number of what I call spasms has declined since she has been on nasal steroids, but they still exist. In patients with secondary polycythemia, the increased erythropoietin may be appropriate or inappropriate. Human toxocariasis and the visceral larva migrans syndrome: Correlative immunopathology. Accumulating evidence indicates that aerosols generated from flavoring agents may contribute to oxidative stress and inflammatory events within the airways. Parasitology 160 Fasciola giagantica (The giant liver fluke) Geographical Distribution:-Widely distributed in tropical Africa including Ethiopia, and Far East, south and south East Asia. While the value of different animal species may be equivalent for risk identification, differences may emerge during risk characterization and establishment of safety margins. The Hallmark Gene Sets were originally generated by Liberzon and colleagues to represent defined biological processes and coordinated expression patterns. Tritrichomonas foetus causes persistent large-bowel diarrhea in cats less than 1 year of age, with chronic colitis and variably apparent crescent-shaped organisms being the corresponding histologic findings. Potentially, the prodromal stage is followed by the excitative phase with severe agitation and aggressiveness. A one-inch hole is drilled or cut into the wall for the entry of the three-foot long inspection device that can thus check both ways three feet up and three feet down from the entry hole. Summary of findings table: Children with steroid-resistant nephrotic syndrome Chlorambucil versus Indomethacin. Resistant varieties have been identified, but resistance has been overcome by increasingly virulent strains of the bacterium (Fregene and Puonti-Kaerlas, 2002; Hillocks and Wydra, 2002). The articular surface has the same mottled white appearance as shown for the femur. These standards are supplemented by regulations and controls for other gaseous pollutants. Multiplatform serum metabolic phenotyping combined with pathway mapping to identify biochemical differences in smokers. Where comparisons have been made for species using both microsatellite markers and allozyme markers, it appears that the allozyme estimates may underestimate true outcrossing rates by up to 10% (Byrne, 2008). Similar clinical findings to maxadilan were observed in the rat following doses of 0. Deficiencies of C1 esterase inhibitor result in recurrent angioedema, which refers to episodic nonpitting edema of soft tissue, such as the face. How to design a parasite control program for the first year of life: Focus on Parascaris equorum, in Proceedings. A 10-month-old, previously healthy male infant develops a severe, watery diarrhea 2 days after visiting the pediatrician for a routine checkup.
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Psoriasis produces parakeratosis and elongated rete ridges but no abnormal cells in the epidermis. Glucose-6-phosphate dehydrogenase deficiency Thalassemia Hereditary spherocytosis Drug-induced hemolytic anemia Normal response 186. Cats can be infected by transmammary transmission, by ingestion of paratenic hosts, or by ingestion of infective eggs. Peripheral blood shows an absolute lymphocytosis, and many lymphocytes are atypical with irregular nuclei and abundant basophilic vacuolated cytoplasm. Prolonged exposure did not further increase inhibition of neuronal activity compared to acute exposure. It is listed as a Category B bioterrorism agent/toxin by the Centers for Disease Control and Prevention due to the potential use as a weapon of terrorism and as a biological warfare threat to military operations. Mining has been a dominant industry in rural Appalachia for more than 150 years, but the impact of mining on aquatic animal health is not well understood. Lack of resistance genes is a major bottleneck that limits the success of conventional cowpea breeding. In chelonians, herpesviruses have been associated with several disease complexes, which are characterized by diphtheritic-necrotizing stomatitis, hepatitis, rhinitis, tracheitis, and pneumonia in tortoises. A Supervising Officer shall arrange with the Ministry of Health and Quality of Life for the timely re-examination of an officer found temporarily unfit. Nonviral inclusions have been demonstrated in cells infected with other retroviruses, such as avian leukosis virus, visna virus, and simian immunodeficiency virus. A systematic review and meta-analysis of pregnancy outcomes in patients with systemic lupus erythematosus and lupus nephritis. This animal had survived previous bouts of both aspiration pneumonia and congestive heart failure and was treated for both based on echocardiographic and radiographic findings. A localizing role for the antigen itself may explain why different complexes damage different organs. It was also shown to produce a range of effects in rats that were entirely consistent with previously reported effects in animals and humans. Currently it is difficult to prospectively estimate human toxicokinetics (particularly for novel chemicals) in a high-throughput manner. The impact of these microvascular toxicities will be discussed from a bench-to-bedside, cardiovascular health perspective. These approaches combine rapid literature assessments, computational toxicology, and in vitro toxicology. Humid summer air may condense on any surface not insulated from cool earth - creating the damp, musty conditions found in many basements during the summer months. People can become infected with Rift Valley fever after being bitten by an infected mosquito or through close contact with acutely infected animals or their tissues. Erianthus rockii is a wild species originating in the Yunnan, Sichuan and Tibetan regions of China (Aitken et al. This offers great potential to screen for seizurogenic liability in an in vitro system. The examination of human cases, however, has not demonstrated the presence of hypersensitivity in man (Dorchies, 1997). Older children and adolescents frequently have fever, coughing spells, nausea, vomiting, and dyspnea during the first week, and the symptoms may recur for several months. Once a facility submits the appropriate application(s), the permitting authority develops a permit for that particular facility based on the information contained in the permit application. Then the mold growth needs to be physically-removed by power planer, power grinder with wire brush attachment, and power sander. Some vascular spaces contain thrombi with fibrin arranged as lines of Zahn separated by red and white blood cells that are occasionally attached to the vascular wall by fibrous tissue. Typical destructive testing performed to gain access for visible inspection and surface sampling should be avoided. The zoonotic species are Dermanyssus gallinae, a parasite of chickens, turkeys, pigeons, canaries, and wild fowl, and Liponyssoides (Allodermanyssus) sanguineus, found on small rodents. Traditionally, observation of the existence of hybrid plants, and the frequency of hybridisation, has depended on the examination of morphological characters, the expectation being that hybrid individuals will possess a mixture of characters and/or characters intermediate between those of the pure bred progenitors.
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In several extraocular cases, definitive diagnosis was obtained by laparotomy and resection of a visible granuloma on the surface of the liver. The pleura was thickened and multifocally adhered to the dorsal and lateral thoracic walls. Should we therefore be looking to screen compounds in early discovery against a panel of ion channels, and what would this panel look like? Overall, the quality of evidence on the important endpoints complete remission and leukopenia is graded as 258 moderate because of study limitations. Pay special attention to filter racks, drain pans, bends and horizontal sections of air ducts where debris can collect. Drug toxicity is a leading cause of attrition at late stages of development and a major reason for post-marketing withdrawal. A 46-year-old woman presents with a 4-month history of a discharge from the nipple. Acute cystitis Acute prostatitis Gonococcal urethritis Interstitial cystitis Nongonococcal urethritis 352. A section from her heart at the time of autopsy reveals marked thickening of the right ventricle, but the thickness of the left ventricle is within normal limits. Similarly, the mesothelium lining the intercostal muscles (not submitted) is ulcerated and replaced by a sheet of fibrin. Therefore, there is a need for more robust in vitro models that reflects in vivo liver biology more accurately and maintains the liver functions for a longer time. The most important predictors of outcome are the level of penetration into the subepidermis and reticular dermis (Clark levels I through V: I, in situ, V, invasion of subcutaneous fat) and the actual depth of invasion, measured in millimeters with an ocular micrometer (Breslow depth). The cysts had a diameter up to 5 cm that were filled with gelatinous to liquid material and contained hydatid sand. The studies to date, however, only measure blood and urine biomarkers, where it is unknown if these biomarkers are suitable surrogates for lung inflammation and disease risk. A newborn female is being worked up clinically for several congenital abnormalities. IgM>1:256, IgG negative or IgG 1:64 or greater: 11 111 164 77 1017 25-160 100-1200 mg/dL U/L 42 157 11. Zebrafish embryos are externally fertilized, which enables direct exposure of the developing embryo, obviating the requirement for maternal exposures. In adults, the wider spectrum of possible underlying glomerular diseases had often necessitated a kidney biopsy in most nondiabetic patients prior to treatment. Gross Pathology: this young female Border collie was extremely thin, with no subcutaneous or internal body fat present. Technician Simpson used poor judgment, drank too much and said things she regretted. Therefore, many of these plant species may act as adjuvants in the treatment of bacterial infections on one hand, as well as in mitigating the pathogenesis of inflammatory diseases due to their promising anti-inflammatory effects. Observational studies indicate L&Z reduce risk for chronic diseases including cancer. Mumtaz the demand and consumption of functional food has grown significantly worldwide in recent years as people become more health conscious. The Work Group also judged that the risk of harms from prolonged high-dose corticosteroid treatment, including metabolic complications, increased risks for infections, and effects on bone health, would be important to patients. This material could be either strongly sorbed hydrocarbon or partially degraded hydrocarbon that was coupled to humic materials in the compost. Commonly involved systems are the upper and lower respiratory tract, skin, eyes, and the nervous system. After the restoration process, surveillance of occupants for sickness, allergy, and sensitivity may also provide a measure of the adequacy of the clean-up operation. A lack of harmonization between methodologies introduces confusion and variations in the application of regulatory guidance and determinations of safe, oral doses in humans.
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This cycle accompanies a seasonal cycle, as the earliest infections arise in late spring and taper off in the fall. Occasional focal groups of tumor cells are arranged in a ring around a central space. Candidiasis is the most common fungal infection of the vagina and is especially common in patients who have diabetes or take oral contraceptives. Biological, economic, cultural and political factors influence how men and women are affected by, and are made vulnerable to , diseases and related health risks. Beobachtungen zum Sandfloh (Tunga penetrans) bei Mensch und Hund in Franzosisch Guayana. The temperature is lowered so the primers bind to their complementary matching sequences on the template (annealing). Good quality reads were aligned to the human reference genome using Bowtie2, and differential expression of transcripts was detected using Cuffdiff. Additionally, 68 patients have a diagnosis code of 311 and do not have the major depression/ dysthymia diagnosis codes. But this line of questioning makes a big assumption- that everyone views "gold treatment" the same way. No treatment related changes in terminal body weight, clinical chemistry, or histopathology were observed at doses of 30, 100, or 300 mkd. As a general trend, the equivalent mixing volume appears to increase with smoking exposure whereas it decreases with asthma. What type of cyst is characteristically located in the lateral (or anterolateral) portion of the neck, is derived from remnants of the pharyngeal apparatus, and does not move with swallowing? Laboratory Diagnosis:-Finding the trophozoites in unstained or stained preparation of vaginal or urethral discharges, urine sediment, vaginal swab, prostate secretions. There was also significant reduction in hanging latency in the wire grip and inverted wire mesh grid grip test. Necrotic hepatocytes are disassociated, rounded up, with swollen or shrunken hypereosinophilic cytoplasm and pyknoti, or karyorrhectic nuclei. The fragile X syndrome, which is more common in males than females, is one of the most common causes of familial mental retardation. Insertion of these molecules into the target cell membrane allows the entry of granzymes, proteolytic enzymes that activate the caspase cascade and thus initiate apoptosis. It is well-known that rodents are more prone than humans to serum T4 binding competition and displacements due to differences in thyroid hormone binding proteins, affinity, and turnover rates. Multifocally within the white matter, there are numerous dilated axons (spheroids) surrounded by dilated myelin sheaths. Which one of the listed statements is the best histologic definition of an abscess? The trypomastgotes invade the reticuloendothelial cells near the point of entry and multiply intracellularly as amastigotes. It is not the intent of this prespray to effect full disinfection because the presence of organics precludes this. Among pets and laboratory animals, the mite is found in dogs, rabbits, hamsters, and some nonhuman primates. Entering Patient Population Counts for Depression Measures - Primary Care Clinics Entering your patient population counts for this screen: All counts pertain to the current measurement period. Seventy-five chemicals with known in vivo inhalation toxicity effects, and covering a broad range of toxicity classes, chemical structures and physical properties, were evaluated. Our findings support and extend previous studies of e -cigarette induced cytotoxicity. Such variation is also reflected in traits such as pest and pathogen resistance (Guimaraes et al. Tobacco smoking is the most significant modifiable risk factor in the development of cardiovascular disease. Moreover, only a particularly discerning technician would note that the eggs he or she is observing are larger than usual, so many cases of human infection caused by T. For example, Botryosphaeria australis has been found infecting plantations of introduced E. Complement is activated by acidosis, such as with exercise or sleep, which can produce red morning urine.
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References:
- https://www.uvm.edu/sites/default/files/media/TRE_UVMLaughing_River.pdf
- https://bmcpublichealth.biomedcentral.com/track/pdf/10.1186/s12889-015-2538-z.pdf
- https://oncologypro.esmo.org/content/download/44473/831588/1/Testicular-Cancer-Rosti-Garolla.pdf